For this one-time announcement, the NCI expects to fund one STRAP and to commit up to $2 million in total costs to this IRM STRAP initiative. No additional funding is planned. One-time supplemental funding will be provided to the grants collaborating in the STRAP. Supplemental funds may be carried over to support the approved STRAP activities in subsequent years, within the funding duration of that parent grant. Funding may not exceed the number of years remaining on the parent grant. Each collaborating parent grant must have at least 2 remaining years of funding.

July 15, 2010

NCI is accepting requests for administrative supplements (up to $2 million – total costs) to existing NCI funded grants of the following types: R01, P01, P30, P50, U01, U10, U19, or U54. This initiative is a part of the NCI Special Translational Research Acceleration Project (STRAP) Program. The overall purpose of the STRAP Program is to accelerate integrated research and development, including support of collaborative activities.  A STRAP should take advantage of an opportunity to move translational research projects to the point of initiating clinical studies. Unique aspects of the STRAP Program are to support translational projects that would be delayed or are not easily done through the usual NCI funding mechanisms and to provide to these projects NCI resources that have been identified by the scientific community as critical to progress.
 
The STRAP Program follows the concept of translational research as a set of developmental pathways focused on various clinical goals (as defined by the NCI-sponsored Translational Research Working Group,  http://clincancerres.aacrjournals.org/content/14/18/5664.full.pdf+html).

This administrative supplement funding opportunity from the STRAP Program is focused on the Immune Response Modifier (IRM) pathway (http://clincancerres.aacrjournals.org/cgi/reprint/14/18/5692.pdf). Any proposed activities to be supported by supplemental funding should be within the overall scope of the active parent NCI grant and interested investigators are encouraged to discuss eligibility with their grant Program Director.

This administrative supplement funding opportunity from the STRAP Program is focused on the Immune Response Modifier (IRM) pathway (http://clincancerres.aacrjournals.org/cgi/reprint/14/18/5692.pdf). Any proposed activities to be supported by supplemental funding should be within the overall scope of the active parent NCI grant and interested investigators are encouraged to discuss eligibility with their grant Program Director.

1.  The requests for Administrative Supplements must be based on eligible “parent” awards that are relevant to translational research on immune response modifiers for cancer prevention and/or therapy.
2. The requestor for each project or subproject component must be the current Principal Investigator (PI) on the eligible parent award.
3. The parent award must be an active, NCI-funded grant or cooperative agreement using one of the following mechanisms: R01; P01; P30; P50; U01; U10; U19; or U54.
4. The parent grant must have at least 2 (full) years of funding remaining at the time of award of an administrative supplement. Requests for no-cost extensions on the parent grant to accommodate a STRAP supplement will not be granted.
5. Administrative supplements may be requested for up to 1 year (see further important information in the NCI IRM STRAP Program Guidelines at http://ccct.cancer.gov/STRAP_Program ).
6. The proposed translational activity must remain within the overall scope of the active “parent” award but must also reflect the outlined developmental milestones defined for the IRM pathway.
7. The proposed activities are expected to bring the prevention or therapy studies under development to the stage of clinical testing.
8. These goals may be proposed though multiple linked requests, reflecting collaborations of several PIs on several eligible parent awards. However, an individual request (from a PI on an eligible parent award) is also allowed. An appropriate plan to manage the collaborative activities must be provided for both scenarios.

          * Multiple eligible PIs/linked requests: PIs on two or more qualifying “parent” awards may jointly identify remaining developmental gaps and define appropriate collaborations to address these gaps. A lead PI must be identified to submit the overall summary plan. Each collaborative unit must meet the eligibility criteria (in terms of eligible parent awards). Individual collaborating requestors must submit their requests jointly. Collaborating PIs may come from the same institution and/or from different institutions.

          * One eligible PI/single request: a PI with a single qualifying “parent” award may request an administrative supplement to address one or more specific gaps in the developmental pathway of focus. If appropriate, the requestor may propose addressing some of the identified gaps through collaborations (funded through subcontracts) with investigators/entities without an eligible parent award. Collaborating investigators may come from the same or different departments within an institution, or from different institutions.

 

For more information, click HERE.